2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141062
    N-Methyl-N'-(azido-PEG2-C5)-Cy5
    N-Methyl-N'-(azido-PEG2-C5)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Methyl-N'-(azido-PEG2-C5)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Methyl-N'-(azido-PEG2-C5)-Cy5
  • HY-134718
    Glycocholic acid-PEG10-iodoacetamide
    Glycocholic acid-PEG10-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Glycocholic acid-PEG10-iodoacetamide
  • HY-159557
    Ethyl-trans-4-benzylcyclohexane-1-carboxylate 1923826-92-9
    Ethyl-trans-4-benzylcyclohexane-1-carboxylate is a PROTAC linker.
    Ethyl-trans-4-benzylcyclohexane-1-carboxylate
  • HY-133319
    Azido-PEG24-Boc
    Azido-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG24-Boc
  • HY-130667
    Ald-Ph-amido-C2-PEG3-azide 1807540-88-0 98.92%
    Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ald-Ph-amido-C2-PEG3-azide
  • HY-76105
    D-Proline, 4-hydroxy-, methyl ester hydrochloride 114676-59-4
    D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
    D-Proline, 4-hydroxy-, methyl ester hydrochloride
  • HY-132066
    Bis-PEG3-t-butyl ester 1611468-29-1
    Bis-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG3-t-butyl ester
  • HY-140517
    N-(Azido-PEG3)-N-bis(PEG3-acid) 2055042-57-2
    N-(Azido-PEG3)-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG3-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-bis(PEG3-acid)
  • HY-140248
    N-(Mal-PEG6)-N-bis(PEG3-amine) 2055040-99-6
    N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Mal-PEG6)-N-bis(PEG3-amine)
  • HY-140595
    m-PEG3-S-PEG1-C2-Boc 2365419-97-0
    m-PEG3-S-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-S-PEG1-C2-Boc
  • HY-140861
    Trityl-PEG10-azide 877239-08-2
    Trityl-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Trityl-PEG10-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Trityl-PEG10-azide
  • HY-140876
    Propargyl-PEG3-methyl ester 2086689-09-8
    Propargyl-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-methyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-methyl ester
  • HY-133334
    Amino-PEG7-acid 2376111-92-9
    Amino-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG7-acid
  • HY-140742
    Benzyl-PEG2-amine 1268135-96-1
    Benzyl-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG2-amine
  • HY-140862
    Phthalamide-PEG3-azide 134179-44-5
    Phthalamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Phthalamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Phthalamide-PEG3-azide
  • HY-140657
    Biotin-PEG-triethoxysilane (MW 1000)
    Biotin-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-triethoxysilane (MW 1000)
  • HY-130449
    N-Boc-N-bis(PEG4-OH) 2093154-01-7
    N-Boc-N-bis(PEG4-OH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG4-OH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-N-bis(PEG4-OH)
  • HY-134749
    Propargyl-PEG2-urea-C3-triethoxysilane 1637329-79-3
    Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-urea-C3-triethoxysilane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-urea-C3-triethoxysilane
  • HY-140692
    mPEG-Mal (MW 20000)
    m-PEG-mal (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-Mal (MW 20000)
  • HY-138709
    Benzyl-PEG6-Ots 129086-11-9
    Benzyl-PEG6-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG6-Ots
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.